One John Marshall Drive

Robert C. Byrd Biotechnology Science Center, Suite 314

Huntington, WV 25755

304-638-6500

info@progenesistechnologies.com

Engineering High Alginate Production

 

The key to viable commercialization of bacterial alginate is to:

  • stimulate high and stable production of this polymer
  • alter the central carbon metabolism pathway so that a maximal amount of the carbon source enters the alginate biosynthetic pathway

 

Progenesis has identified a genetic signal that stimulates high and stable production of alginate in Pseudomonas aeruginosa and also formulated a media composition that allows this new strain of bacteria to produce an average of 100g/L (wet weight) of commercial grade alginate.

 

Progenesis is currently pursuing a strategy of engineering the flow of dihydroxyacetone phosphate into gluconeogenesis and then fostering the production of fructose-1,6-bisphosphate into fructose-6-phosphate, which is used as substrate for the first step of alginate biosynthesis by algA.   (need new diagram of a hybrid of glycerol metabolism and alginate metabolism)

 

 

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