One John Marshall Drive
Robert C. Byrd Biotechnology Science Center, Suite 314
Huntington, WV 25755
Engineering High Alginate Production
The key to viable commercialization of bacterial alginate is to:
Progenesis has identified a genetic signal that stimulates high and stable production of alginate in Pseudomonas aeruginosa and also formulated a media composition that allows this new strain of bacteria to produce an average of 100g/L (wet weight) of commercial grade alginate.
Progenesis is currently pursuing a strategy of engineering the flow of dihydroxyacetone phosphate into gluconeogenesis and then fostering the production of fructose-1,6-bisphosphate into fructose-6-phosphate, which is used as substrate for the first step of alginate biosynthesis by algA. (need new diagram of a hybrid of glycerol metabolism and alginate metabolism)